If you just try and run the installed HoN using this setup you will see the screen go to funny colored blocks and pop back having failed to run. If you run it from the command prompt you can see this message "LibGL error: failed to load driver: r600". So set LIBGL_DEBUG=verbose and try again.
alright, that gives us something to work with, it looks like the C++ runtime libraries that were linked into Xorg Edgers are a higher version then the ones shipped with HoN. Easy fix go delete ~/HoN/libs-x86_64/libstdc++.so.6. Problem solved, HoN now runs at an acceptable framerate and doesnt seem to have any graphical glitches or crashes.warning: The VAD has been replaced by a hack pending a complete rewritelibGL: OpenDriver: trying /usr/lib/x86_64-linux-gnu/dri/tls/r600_dri.solibGL: OpenDriver: trying /usr/lib/x86_64-linux-gnu/dri/r600_dri.solibGL error: dlopen /usr/lib/x86_64-linux-gnu/dri/r600_dri.so failed (/home/hippiehunter/HoN/libs-x86_64/libstdc++.so.6: version `GLIBCXX_3.4.15' not found (required by /usr/lib/x86_64-linux-gnu/dri/r600_dri.so))libGL error: unable to load driver: r600_dri.solibGL error: driver pointer missinglibGL error: failed to load driver: r600libGL: OpenDriver: trying /usr/lib/x86_64-linux-gnu/dri/tls/swrast_dri.solibGL: OpenDriver: trying /usr/lib/x86_64-linux-gnu/dri/swrast_dri.solibGL error: dlopen /usr/lib/x86_64-linux-gnu/dri/swrast_dri.so failed (/home/hippiehunter/HoN/libs-x86_64/libstdc++.so.6: version `GLIBCXX_3.4.15' not found (required by /usr/lib/x86_64-linux-gnu/dri/swrast_dri.so))libGL error: unable to load driver: swrast_dri.solibGL error: failed to load driver: swrastK2 - Fatal Error: ARB_vertex_buffer_object not available.